LISER™ (Laser-Induced Spontaneous Emission of Radiation) is an advanced light source providing high-intensity, broad-spectrum illumination. The system uses a laser pumped Ce:YAG (cerium-doped yttrium aluminum garnet) crystal, which emits a continuous spectrum from yellow to red (500–650 nm).

The LISER™ provides exceptionally high optical power (> 85mW full spectrum in a 200 um NA 0.57 fiber) in a spectral range that is difficult to achieve with standard LEDs or laser diodes, particularly around 590 nm, optimal for activating inhibitory opsins such as NpHR and Jaws. In addition to its broad-spectrum output, LISER™ includes an integrated blue excitation source (laser or LED), making it a versatile, all-in-one solution capable of supporting both excitatory and inhibitory optogenetics simultaneously.

The LISER also includes its own internal drivers, allowing independent control of two wavelength channels in the same brain region (e.g. 450 nm + 590 nm).

Key Features:

•  Full-Spectrum Coverage: Simultaneously delivers blue excitation plus tunable yellow-red wavelengths using interchangeable optical filters (e.g., 525, 559, 582, 593, 612 nm).
•  High-Power: Ideal for experiments requiring intense illumination, including bilateral, and/or large-area stimulation.
•  Supports Large Core Patch Cords for wide brain region illumination: Optimized for 200 - 400 µm core diameters, enabling uniform wide-area stimulation.

For multi-animal or multi-site optogenetics experiments, DazzLED is the optimal solution. This light source can be combined with the DazzLED Fiber Converter and Bundle Branching Fiber Optic Patch Cords to deliver high-power stimulation across many fibers simultaneously.

This configuration enables scalable, high-throughput photostimulation of up to 20 fibers with 400 µm diameter cores or up to 100 fibers with 200 µm diameter cores, making it well suited for parallel optogenetic experiments, multi-region stimulation, and large cohort studies.

To operate Doric LED and Laser diode modules, a dedicated light source driver is required. The driver can either come as a standalone device, or can integrate the ligth source (fiber-light sources, FLS).

• Integrated Driver Units (FLS): In this setup, each driver channel has a built-in LED or laser, offering a compact and user-friendly solution.
• Modular Driver Setup (Driver): The LED/laser remains separate from the driver, provides flexibility to switch between different wavelengths.

The driver can be operated in 1) standalone, 2) external modes (Analog or TTL), or 3) program sequences using free Doric Neuroscience Studio (DNS) software. In DNS, users can define a wide range of light stimulation patterns including continuous wave output, square pulse trains, sine waveforms, and cutoms waveforms.

Watch the tutorial video for step-by-step guidance on using LED drivers.

All light source drivers can be triggered by external digital signals, unlocking the ability to do close-loop experiments, where behaviors (lever press, nose poke, beam break, etc.) trigger the optogenetic stimulation. As such, DNS support complex triggering modes to pause, restart, and continue a stimulation pattern, as described in the following tutorial video.

NOTE:

• LED drivers are only compatible with LEDs, and LD drivers only with lasers.
• LISER come with integrated driver.