Monitoring neuronal activity in freely behaving animals can help decipher brain functioning and its connection to animal behavior. Fiber photometry does just that by using optical fiber to deliver excitation light pulses to a group of neurons labeled with genetically encoded calcium indicators in a behaving animal's brain and to detect fluctuations in calcium-related fluorescence. This requires implanting a small, lightweight fiber-optic cannula above the brain's region of interest.
While it lacks the cellular resolution of fluorescence miniscope, fiber photometry records fluctuation in the calcium activity of a group of neurons in behaving animals using a more straightforward setup.
The cannula's fiber diameter is smaller than that of a miniscope's lens, making it better suited for neuronal activity monitoring in deep tissue. We offer several Fiber photometry systems to fit different fluorescent markers, opsins, and experiment configurations. All those systems are supported with a user-friendly Doric Neuroscience Studio software package.