Optogenetic techniques use the light of appropriate color to activate or inhibit genetically modified light-sensitive neurons. They enable very selective control of specific populations of cells and provide an entirely new set of tools for studying neuronal activity within the brain.
The fiber photometry is a technique of monitoring the neuronal activity of neurons labelled with fluorescent reporter(s) in behaving lab animals that uses chronically implanted optical fiber to deliver excitation light and collects induced fluorescence from the targeted brain region.
MINIATURIZED FLUORESCENCE MICROSCOPY
Miniaturized fluorescence microscopy is a method that uses a light weight and small footprint microscope to record the activity of individual cells and map their spatial position within a network in freely behaving animals.
Miniaturized fluorescence microscopy can also be combined with optogenetics to modulate the cellular activity.
In addition to optical solutions for fluorescence recording or optogenetics light delivery, Doric Lenses provides solutions to combine optogenetics, fiber-photometry or miniaturized fluorescence microscopy with ephys recording with a wireless and tethered recording system and a wide range of solutions for optical fibre and electrodes for chronic implant.
DORIC NEUROSCIENCE STUDIO
Doric Neuroscience Studio is an intuitive software suite with multiple modalities to control Doric hardware, record and analyze data in optogenetics, fiber photometry, miniature fluorescence microscopy, electrophysiology and behavior cameras experiments.