The term "fluorescence lifetime" denotes the time lapse between the laser excitation and the release of fluorescence by the biosensor. Specially designed biosensors have unique lifetime distributions depending on whether they are in bound or unbound states. This disparity can be leveraged to study changes in neurophysiological states of key neural populations, including protein-protein interactions, changes in protein conformation, and the presence of neurotransmitters or other molecules of interest.

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