The 16 channel Ephys Headstage is a small and lightweight electronic component that connects to the electrical part of an opto-electric cannula chronically implanted on the head of a small behaving animal. It amplifies and digitizes the analog signals received from the cannula's electrodes and sends them to an electrophysiology console over a tiny flexible electrical cable or tether. Each headstage contains an Intan RHD2132 amplifier chip and connectors to the digital interface cable and opto-electric cannula.